CHANGES OF COAGULATION IN MEN AND WOMEN WITH ACUTE CORONARY SYNDROME WITH ST SEGMENT ELEVATION

N. V. NETYAZHENKO, A.I. PASTUSHINA, A. V, O.M. HERULA

Abstract


Summary. The article describes the results of a study of hemostasis in women with acute coronary syndrome (ACS) with ST-segment elevation compared to men. 105 patients were examined, 45 of whom were women, On a scale TIMI patients of both sexes were divided into three groups. The I group consisted of 15 women and 20 men with a risk of mortality <1% in group II – 15 women and 18 men with a risk of 1 to 4%, and 15 women and 22 men were the group III with the risk of >4%. The groups were comparable. Research methods plasma coagulation hemostasis included the following tests: activated partial thromboplastin time (APTT), thrombin time (PT), fibrinogen concentration, the amount of soluble fibrin monomer complexes, while XI Ia dependent fibrinolysis. For laboratory evaluation level of natural inhibitors of blood coagulation following methods were used: determination of the activity of antithrombin III and protein C by a chromogenic substrate. Increased risk of mortality within 30 days in ACS scale TIMI associated with the deepening of gender differences in hemostasis, which are most pronounced in high and very high risk. Simultaneous detection of hypercoagulation shifts in a shortening of the aPTT and PT in the high-risk group of women next to decreased activity of antithrombin III and protein C in the moderate and high risk disclose a violation of the balance of procoagulants with the major components of anticoagulant and fibrinolytic systems in women compared with men ACS segment elevation ST.

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