THE EFFECT OF LAPROXIDE L-303 ON THE STATE OF NEUROMEDIATORS, RECEPTOR APPARATUS AND MEDIATOR REGULATORY SYSTEM OF INTRACELLULAR METABOLISM

S.M. KUCHERIAVCHENKO

Abstract


Summary. Laproxide L-303 in 1/100 LD50 was shown to exert membranotropic effects, which is indicated by a reduction in adenylate cyclase activity and cAMP contents, as well as an increase in guanylate cyclase and cGMP activity in the brain and liver. The assessment of glutamate/ guanylate cyclase mediator cascade metabolic system condition in the liver showed an increase in both glutamate and guanylate cyclase mediator cascade, while in the brain glutamate was found to be decreasing in the settings of guanylate cyclase mediator cascade increase. Blood plasma assessment showed a decrease in the number of inhibitory and stimulatory amino acids under the influence of laproxide in 1/100 LD50, which can be associated with an increase in reparatory syntheses aimed at homeostasis maintenance in body toxification. The study of receptor bonding indices showed a decrease in variable of dissociation and the number of dopamine and serotonin receptor bonding sites. Therefore, it is possible to conclude that laproxide L- 303 in 1/100 LD50 is responsible for profound reconstruction of intracellular metabolism regulation systems, interfering with neuromediator exchange, kinetic characteristics of radioligand receptor bonding indices in the settings of inhibition of adenyle cyclase and activation of guanylate cyclase mediator cascade. In 1/1000 LD50 laproxide was not found to have an effect on intracellular metabolism regulation systems.

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