MORPHOLOGICAL CHANGES OF PITUITARY- ADRENAL SYSTEM OF RATS AFTER THERMAL INJURY

O.I. CHERKASOV, O.I. KOVALCHUK, I.V. DZEVULSKA, ,V.N. TITARENKO, A.V. MALIKOV

Abstract


Summary: on the experimental model of the local thermal burn we investigated reactive changes of the pituitary-adrenal system in rats. In burned rat installed nonspecific destructive changes parenchymal and stromal elements of the adenohypophysis and adrenal glands. Changes characterized three phases of the development of organ dysfunction: 1-3 days – microcirculatory disorders and degenerative changes of initiation; 7-14 day – the progression of degenerative changes and stabilization; 2130 day – activation of regenerative processes and hemodynamics. In the pathogenesis of burn injury leading place has regional hemodynamic changes. Microcirculation disturbance cause ischemic cell injury, development of dystrophic disorders and in critical hypoxia caused tissue necrosis.

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